A lot of the time we program conservatively until we see how the first part runs and tweak from there.
For example I'm roughing a 8x8x8 block on the horizontal right now only holding onto it by a .150 deep dovetail with a Technigrip.
First part I'll run .075 deep 75% stepover. There are 12 faces around the part, IE 12 face mill operations. Is it possible to make the DOC = variable 1 and the stepover = variable 2?
After the first part I can just change these settings in 1 place and have all my affected tool paths be ready to regenerate? Really sucks having to go into each 1 by 1 to change the same setting.
There are examples shipping with NX in the folder %UGII_BASE_DIR%\UGOPEN\SampleNXOpenApplications\.NET\CAM, see any of the CycleAll samples as a starting point.
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It depends on how you make the "other" 11 operations.
If they are pasted with reference, then you only have to change the first (parent) operation.
You could probably do something similar with instances.
If you always want to mass edit the same parameters, like Stefan said, use a journal.