That's not so easy to answer. To use Advanced simulation, you do not really require fem knowledge. But that is basically creating a fem file, applying loads and solving the Sim file. It's not that hard.
But however, interpreting the outcome data, and knowing if this is correct is a whole other thing. Besides this, setting up a simple model, Mesh the Fem, and applying loads is easy. However when you create more complex models, that need tweaks in the fem in order to solve nicely. Use 1D, 2D and/or 3D meshing. Combine these techniques, and know what the properties are of these mesh types is not so easy and probably require a lot more knowledge.
Also apply more than a simple load also requires more knowledge. Is it a simple force, or will you be applying a much more complex loads on a model.
It really depends on what you want to achieve, and how complex you want to make it. But some basic understanding is highly recommended.
Dennis de Brouwer Application Support Engineer GTAC EMEA - Siemens Industry Software