I have not tried my tablet yet, but since it works the same as a mouse, it should just plain work. Macro and custom buttons on the tablet may or may not be able to be mapped to functions but anything with a keyboard shortcut should be able to be programmed to the tablet hot keys area or the button puck in the Summasketch software.
Ok, so now I have a question... Does the Tablet Works software allow you to assign keyboard keys to the puck buttons? Since my puck seems to be gone I don't want to buy a new one just to find out that I can't assign things like the function keys to a button. I thought this was part of the Wintab software which no longer works with the USB connections but I might be wrong since it has been several years since I used my tablet.