I opened your file, edited E and one of the holes moved.
That appears to be working just fine. To me the trick is getting a spreadsheet tied in that can be edited. The other thing I would look at is displaying a name based one changing dimensions so that you can edit, print, repeat. Ending up with a bunch of PDF's that all have different names and drawings.
If you have the file open and the holes dont move like they should try saving and reopening. I have had many problem with file updating correctly once they have been editied.