You can use the comment palne to normal curve. just before making an hole, just draw the line where you want to make hole with required angle. the create a hole with the refernce of that line with the option of Plane normal to curve.
here You have a first video, showing how I create such a hole using sync capabilities.
If You are placing a sync hole it is oriented radial when moving over the cylinder
If pressing F3 or click the lock symbol You are in tangent plane mode automatically.
So You can place the hole under a specific angle.
Or You rotate it afterwards by using the steering wheel.
Or You place an angular dimension to them.
Hi there @shreeharsha1,
In addition to @hawcad's great info.....if you were looking to place a hole angular to the shaft axis, maybe this will help too.
Part file [ST9] also attached....first I placed a sketch line to be the hole axis, then placed a new "Plane" - "Normal to Curve", placing the hole on that plane located to the line endpoint, then, because Synchronous only temporarily uses sketches, I placed dimensions on the hole.....as evident in my screenshot, the construction axis was 60 degrees, and the Sync dimension to the hole feature can be edited to whatever angle, in this case, 45 degrees, plus my inset dimension of 40mm.
Design Manager Streetscape Ltd
Solid Edge ST10 [MP2] Classic [x2 seats]
Windows 10 - Quadro P2000