No, you can't use the boolean tools, such as "Subtract" on regular frame entities, but you can make cutouts, etc....you'd need to right click on the frame Save As Translated, to publish to full model level component(s) if that was specifically what you needed.
Design Manager Streetscape Ltd
Solid Edge ST10 [MP8] Classic [x3 seats]
Windows 10 - Quadro P2000
Testing: Solid Edge 2019