No, you can't use the boolean tools, such as "Subtract" on regular frame entities, but you can make cutouts, etc....you'd need to right click on the frame Save As Translated, to publish to full model level component(s) if that was specifically what you needed.
Thanks for the explanation.
Actually Save as Translated is what for?
I attach the Picture...I want to cut the frame base on the circle on TOP. It will be easier if I can use Subtract.