If you install 2tier then you won't need the web application but you will be restricted by latency to remain close to the DB server (and TC_DATA). 4tier, as the name implies, requires the web application. You might be able to tinker with the application files to disable the thin client (like removing the login page). Give GTAC a call.
NX 11.0.1.mp01 | SW 2016 | TcUA 11.2.3